Eosinophilic gastrointestinal disorders (EGIDs) in children


Digestive Disorder

Eosinophilic gastrointestinal disorders (EGIDs) are chronic digestive system disorders in which certain food proteins trigger an overproduction of eosinophils (white blood cells that help fight certain infections), in different areas of the digestive tract.

EGIDs typically fall into one of three types:

Eosinophilic esophagitis (EoE): EoE is the most common and difficult type of EGID to manage. It is characterized by inflammation of the esophagus due to abnormally high levels of eosinophils in that area of the GI tract. Symptoms can include abdominal pain, diarrhea, nausea, severe vomiting, difficulty swallowing, and, at times, obstruction.

Eosinophilic gastroenteritis: Associated with eosinophils and inflammation in the stomach and small intestine

Eosinophilic colitis: Associated with eosinophils and inflammation in the large intestine

Common symptoms of EGIDs

  • Vomiting or nausea
  • Abdominal or chest pain
  • Acid reflux that does not respond to usual therapy
  • Bloating
  • Blood in the stool
  • Diarrhea
  • Poor growth or weight gain
  • Difficulty swallowing
  • Gastroparesis
  • Malnutrition
  • Anemia


How to manage EGIDs

Your doctor may be able to identify specific food proteins that trigger the overproduction of eosinophils in your child. Your doctor may recommend an elimination diet where the offending proteins are not consumed. Often a stricter diet — an amino acid-based diet — is prescribed.

About Author


As well as being one of the founding members of refluxSUPPORT...Jonathan is a Board Member and trustee of Living with Reflux – the only UK Charity for infants with reflux related conditions.He is also a stakeholder in the National Institute for Health and Care Excellence (NICE) – Gastro-oesophageal reflux in children and young people.He has three daughters of which the eldest is now seventeen. Two suffered from severe reflux.